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checkpoint inhibitors icis  (Janssen)

 
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    Janssen checkpoint inhibitors icis
    Checkpoint Inhibitors Icis, supplied by Janssen, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/checkpoint inhibitors icis/product/Janssen
    Average 86 stars, based on 1 article reviews
    checkpoint inhibitors icis - by Bioz Stars, 2026-05
    86/100 stars

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    Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and αCTLA4. Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).

    Journal: iScience

    Article Title: Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer

    doi: 10.1016/j.isci.2025.114552

    Figure Lengend Snippet: Therapeutic efficacy of the Ad-PS2 vaccine combined with ICIs Note the complete regression of tumors in mice treated with the Ad-PS2 vaccine and αCTLA4. Data pooled from two independent experiments (5 mice per group; n = 10) are represented as mean ± SEM. The main comparison is between the combination of the Ad-PS2 vaccine with αCTLA4 and the control groups; no statistical analysis was performed due to complete tumor regression (A) and tumor-free survival (B).

    Article Snippet: Anti-mouse immune checkpoint inhibitor (ICI) antibodies for αCTLA4 (Cat. #BP0164; Clone #9D9) and αPD1 (Cat. #BP0146; Clone # RMP1-14) were purchased from BioXcell (Lebanon, NH, USA).

    Techniques: Drug discovery, Comparison, Control

    Therapeutic efficacy of the Ad-PS2 vaccine combined with different doses of αCTLA4 (A) Overall measurement of tumor growth in mice injected with 100 or 200 μg of αCTLA in combination with the Ad-PS2 vaccine; (B) tumor growth curve for individual mouse receiving 100 μg of αCTLA ± Ad-PS2 and control groups pooled from two independent experiments ( n is the number of mice), and (C) rechallenging of tumor-free mice treated with the Ad-PS2 vaccine combined with αCTLA4 from two sets of experiments ( n = 9). Data are represented as mean ± SEM.

    Journal: iScience

    Article Title: Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer

    doi: 10.1016/j.isci.2025.114552

    Figure Lengend Snippet: Therapeutic efficacy of the Ad-PS2 vaccine combined with different doses of αCTLA4 (A) Overall measurement of tumor growth in mice injected with 100 or 200 μg of αCTLA in combination with the Ad-PS2 vaccine; (B) tumor growth curve for individual mouse receiving 100 μg of αCTLA ± Ad-PS2 and control groups pooled from two independent experiments ( n is the number of mice), and (C) rechallenging of tumor-free mice treated with the Ad-PS2 vaccine combined with αCTLA4 from two sets of experiments ( n = 9). Data are represented as mean ± SEM.

    Article Snippet: Anti-mouse immune checkpoint inhibitor (ICI) antibodies for αCTLA4 (Cat. #BP0164; Clone #9D9) and αPD1 (Cat. #BP0146; Clone # RMP1-14) were purchased from BioXcell (Lebanon, NH, USA).

    Techniques: Drug discovery, Injection, Control

    Preclinical evaluation of the toxic profile of the Ad-PS2 vaccine combined with αCTLA4 therapy (A) Scatterplot of the counted inflammatory cells in the liver (3 different fields at 40x) between age-matched naive mice and vaccine-treated groups of mice ( n = 3) based on histopathology studies, and (B) liver panel analytes measured in serum among the naive ( n = 3), Ad-LacZ control ( n = 5), Ad-PS2 vaccine ( n = 7), and Ad-PS2 + αCTLA4 ( n = 3) groups of mice. Data are shown as mean ± SEM with a significant difference (∗ p < 0.05) and ns = non-significant following a nonparametric Kruskal-Wallis test.

    Journal: iScience

    Article Title: Combined prostate cancer vaccine plus immune checkpoint inhibition synergizes to eliminate prostate cancer

    doi: 10.1016/j.isci.2025.114552

    Figure Lengend Snippet: Preclinical evaluation of the toxic profile of the Ad-PS2 vaccine combined with αCTLA4 therapy (A) Scatterplot of the counted inflammatory cells in the liver (3 different fields at 40x) between age-matched naive mice and vaccine-treated groups of mice ( n = 3) based on histopathology studies, and (B) liver panel analytes measured in serum among the naive ( n = 3), Ad-LacZ control ( n = 5), Ad-PS2 vaccine ( n = 7), and Ad-PS2 + αCTLA4 ( n = 3) groups of mice. Data are shown as mean ± SEM with a significant difference (∗ p < 0.05) and ns = non-significant following a nonparametric Kruskal-Wallis test.

    Article Snippet: Anti-mouse immune checkpoint inhibitor (ICI) antibodies for αCTLA4 (Cat. #BP0164; Clone #9D9) and αPD1 (Cat. #BP0146; Clone # RMP1-14) were purchased from BioXcell (Lebanon, NH, USA).

    Techniques: Histopathology, Control